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It cannot compensate for every cause of oxidative stress or poor health

Furthermore, cooking, processing, preserving, storing food generally causes the natural glutathione to deteriorate

Higher mitochondrial metabolism in the neurons result in generation of Complex I dependent hydrogen peroxide and neuronal membranes, rich in polyunsaturated fatty acids, are particularly vulnerable to oxidative stress due to their possession of unsaturated double bonds

Moreover, dopamine-mediated cAMP activity was notably absent from human macrophages (Nickoloff-Bybel et al., 2019), suggesting that this pathway might not function in human cells